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September 5, 2025GliaOpen Access

C9orf72 Repeat Expansion Induces Metabolic Dysfunction in Human iPSC‐Derived Microglia and Modulates Glial‐Neuronal Crosstalk

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Authors

MMMarika MearelliIHInsa HirschbergCWChristin Weissleder

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Overview

Research reveals metabolic dysfunction in microglia and its implications for neuronal health in ALS, indicating immune-targeted therapies.

Key Points

  • C9orf72 repeat expansion leads to significant metabolic dysfunction in microglia, impacting overall cellular health.
  • Microglia exhibited increased glycolytic activity and oxidative stress, highlighting key changes in metabolic pathways.
  • An iPSC-derived triculture model demonstrated intercellular crosstalk, where microglia influence astrocytic metabolism.
  • Findings suggest potential therapeutic approaches by targeting metabolic pathways in immune cells to combat ALS.

Cite This Study

Mearelli et al. (2025) studied this question.

synapsesocial.com/papers/68bb49db6d6d5674bcd0055ehttps://doi.org/10.1002/glia.70080
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