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September 16, 2025GliaOpen Access

Altered Inflammatory Signature in a C9ORF72‐ALS iPSC‐Derived Motor Neuron and Microglia Coculture Model

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Authors

YGYujing GaoJBJessica L. BrothwoodHSHarpreet K. Saini

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Overview

This analysis reveals altered inflammatory responses in C9ORF72 ALS models, highlighting microglia's role in neuroinflammation.

Key Points

  • Altered inflammatory response was observed in C9ORF72 iPSC-derived microglia, indicating dysfunction in ALS.
  • Key evidence shows significant changes in cytokine and chemokine secretion in C9ORF72 HRE and KO microglia.
  • The analysis involved iPSC-derived motor neurons alongside microglia in both mono- and cocultures for phenotypic assessment.
  • These findings highlight the potential of iPSC-derived models to advance our understanding of ALS pathology.

Cite This Study

Gao et al. (2025) studied this question.

synapsesocial.com/papers/68d44f8331b076d99fa56fdfhttps://doi.org/10.1002/glia.70084
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  4. 4Dysregulated Expression of Inflammasome and Extracellular Matrix Genes in <i>C9orf72</i> -ALS/FTD Microglia2025
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