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September 5, 2025Open Access

IL-27 limits HSPC differentiation during infection and protects from stem cell exhaustion

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Authors

DADaniel L. AldridgeZLZachary LanzarAPAnthony T. Phan

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Overview

Findings reveal IL-27's role in regulating HSPC differentiation during Toxoplasma gondii infection, implicating cytokine signaling in stem cell fitness.

Key Points

  • IL-27 reduces monocyte differentiation from hematopoietic stem and progenitor cells, protecting stem cell function.
  • Mice lacking IL-27 showed an increase in monocyte progenitors after Toxoplasma gondii infection.
  • HSPCs are uniquely responsive to IL-27, indicating a specific regulatory mechanism in emergency myelopoiesis.
  • Loss of IL-27R led to decreased HSPC fitness and impairments in reconstituting the hematopoietic system.

Cite This Study

Aldridge et al. (2025) studied this question.

synapsesocial.com/papers/68bb4d196d6d5674bcd009a1https://doi.org/10.7554/elife.105876.2
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