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September 5, 2025Medical Principles and PracticeOpen Access

The Mechanisms Associated with Inflammation and Coronary Microvascular Dysfunction in The Heart Failure with Preserved Ejection Fraction

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Authors

XYXiaoli YanRWR.Z. WangHXHui Xu

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Overview

This review explores inflammation's role in coronary microvascular dysfunction in HFpEF, highlighting therapeutic strategies to address associated comorbidities.

Key Points

  • Inflammation contributes significantly to coronary microvascular dysfunction in HFpEF, complicating treatment.
  • HFpEF affects a diverse population, including those with comorbidities like obesity and diabetes, indicating the need for targeted therapies.
  • The review investigates molecular links between inflammation and CMD, suggesting new avenues for therapeutic interventions.
  • Understanding these mechanisms may improve prognosis and expand therapeutic options for HFpEF patients.

Cite This Study

Yan et al. (2025) studied this question.

synapsesocial.com/papers/68bb4d196d6d5674bcd00beehttps://doi.org/10.1159/000548233
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Molecular and Cellular Mechanisms Associated with a Microvascular Inflammation in the Pathogenesis of Heart Failure with Preserved Ejection Fraction2020 · 22 citations
  2. 2Coronary microvascular dysfunction and its role in heart failure with preserved ejection fraction for future prevention and treatment2025 · 14 citations
  3. 3Focusing on microvascular function in heart failure with preserved ejection fraction2025 · 10 citations
  4. 4The role of coronary microvascular dysfunction in the pathogenesis of heart failure with preserved ejection fraction2024 · 2 citations
  5. 5The Role of Systemic Microvascular Dysfunction in Heart Failure with Preserved Ejection Fraction2022 · 36 citations