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January 13, 2025Heart Failure ReviewsOpen Access

Coronary microvascular dysfunction is highly prevalent in HFpEF (up to 81% in invasive studies) and is associated with poor clinical outcomes, though current therapies show limited success.

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Why the study?

Effective therapies for HFpEF remain limited due to pathophysiological heterogeneity and incomplete understanding of underlying mechanisms, with the exact causal relationship between coronary microvascular dysfunction and HFpEF remaining unclear.

Design

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Authors

OVOrnela VelollariKRKarl‐Philipp RommelKKKarl‐Patrik Kresoja

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Overview

Hypothesis-generating for microvascular-targeted therapies in HFpEF; prospective trials needed before clinical adoption.

Key Points

Key points are not available for this paper at this time.

Cite This Study

Velollari et al. (2025) studied this question.

synapsesocial.com/papers/6a10836b2badbc352a002bb9https://doi.org/10.1007/s10741-024-10479-7
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The role of coronary microvascular dysfunction in the pathogenesis of heart failure with preserved ejection fraction2024 · 2 citations
  2. 2Coronary microvascular dysfunction and its role in heart failure with preserved ejection fraction for future prevention and treatment2025 · 14 citations
  3. 3Coronary microvascular disease in heart failure with preserved ejection fraction2025 · 13 citations
  4. 4Coronary Microvascular Dysfunction in Heart Failure with Preserved Ejection Fraction – Adding New Pieces to the Jigsaw Puzzle2020 · 4 citations
  5. 5The Mechanisms Associated with Inflammation and Coronary Microvascular Dysfunction in The Heart Failure with Preserved Ejection Fraction2025 · 9 citations