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September 5, 2025Molecular Pharmaceutics

Preparation and Evaluation of Upadacitinib-Loaded Binary Ethosomal Hydrogel: A Topical Delivery System with Enhanced Stratum Corneum Permeability for Improved Anti-Inflammatory Therapy in Psoriasis

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Authors

ZXZihao XiongCSChang-Woo SongYOYouming Ou

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Overview

In vivo evaluations demonstrate a binary ethosomal hydrogel significantly reduces pro-inflammatory cytokines, suggesting improved anti-inflammatory therapy in psoriasis.

Key Points

  • The upadacitinib-loaded carbomer hydrogel significantly improves stratum corneum permeability for psoriasis treatment.
  • In vitro, the ethosomal hydrogel showed a penetration rate of 7.04 μg/cm2·h, a 2.3-fold increase over the cream.
  • In vivo results indicate a significant reduction in TNF-α levels from 361.97 to 262.11 pg/mL, among other cytokines.
  • The hydrogel formulation demonstrated no significant irritation, indicating its safety for topical application.

Cite This Study

Xiong et al. (2025) studied this question.

synapsesocial.com/papers/68bb4d206d6d5674bcd00de2https://doi.org/10.1021/acs.molpharmaceut.5c00647
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