Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 16, 2025Macromolecular Bioscience

A Double‐Layer Microneedle Patch Containing Methylprednisolone and Upadacitinib‐Loaded Mesoporous Silica Nanocomposites for Psoriasis Treatment

View Full Paper
Ask AI
Bookmark
Share

Authors

DLDie LiTWTing WangYLYi Liu

Discussion

Loading...

Member takes

Overview

This approach reduced psoriasis severity by 90% and enhanced treatment efficacy, suggesting improved delivery of glucocorticoids and JAK1 inhibitors.

Key Points

  • Approximately 90% reduction in psoriasis severity observed with the microneedle patch.
  • The formulation released 70% of methylprednisolone within 2 hours, sustaining upadacitinib for 48 hours.
  • Assessment using a mouse model demonstrated significant inhibition of inflammatory markers.
  • Potential for personalized psoriasis treatment through effective transdermal delivery and reduced toxicity.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/692509ffc0ce034ddc3532c1https://doi.org/10.1002/mabi.202500530
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A bilayered microneedle patch loaded with methotrexate and dexamethasone for transdermal treatment of psoriasis2026 · 1 citations
  2. 2Innovative Microneedle Patches for Psoriasis Treatment: A Dual Approach With Methotrexate‐Zinc and Difelikefalin for Enhanced Therapeutic Outcomes2026 · 1 citations
  3. 3Calcipotriol Nanosuspension-Loaded Trilayer Dissolving Microneedle Patches for the Treatment of Psoriasis: In Vitro Delivery and In Vivo Antipsoriatic Activity Studies2024 · 14 citations
  4. 4Preparation and Evaluation of Upadacitinib-Loaded Binary Ethosomal Hydrogel: A Topical Delivery System with Enhanced Stratum Corneum Permeability for Improved Anti-Inflammatory Therapy in Psoriasis2025
  5. 5Self-Adhesive Sustained-Release Paeoniflorin Hydrogel Microneedles Achieve Effective Treatment of Psoriasis2026