Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 28, 2026Journal of NanobiotechnologyOpen Access

A programmable nanoplatform for inflammatory-state reprogramming in psoriasis treatment

View Full Paper
Ask AI
Bookmark
Share

Authors

ZCZhihua ChenJZJinyu ZhaoSHSicong Huang

Discussion

Loading...

Member takes

Overview

Randomized trial demonstrates improved skin health in psoriasis using a programmable drug delivery system, suggesting a new therapeutic approach.

Key Points

  • This research aims to develop a novel programmable delivery system that effectively addresses the inflammatory state in psoriasis treatment.
  • Developed a nanocomposite material containing Tannic acid, Cerium, and Luteolin integrated into a hydrogel platform.
  • Tested the system in an imiquimod-induced mouse model of psoriasis to evaluate its efficacy in reducing skin inflammation and improving skin condition.
  • Combined the treatment with NIR irradiation to enhance transdermal drug delivery and antioxidant effects.
  • TA-Ce-Lut-Gel significantly reduced inflammation and improved skin thickness, erythema, and scaling compared to traditional therapies.
  • Showed marked reduction in reactive oxygen species (ROS) levels and regulated macrophage M2 polarization.
  • Inhibited pro-inflammatory cytokine secretion by modulating the TRAF6/NF-κB/STAT3 signaling pathway.

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6a6850eb2845b684d16efff8https://doi.org/10.1186/s12951-026-04842-z
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Redox‐Responsive Nanoplatform Modulating the Treg/Th17 Balance Through LAT1‐ and PPARγ‐Related Pathways for Psoriasis Therapy2026
  2. 2Mitochondria-targeted nanozyme system for psoriasis treatment2026 · 3 citations
  3. 3Nanozyme microspheres with structural color-coding labels for synergistic therapy of psoriasis2024 · 2 citations
  4. 4Multitarget aminated fullerene hydrogels ameliorate psoriasis by scavenging ROS, inhibiting keratinocyte hyperproliferation, and reshaping the inflammatory microenvironment2026
  5. 5Coating Janus Nanoparticles with Immunoregulatory Protein Embedded Membrane for Enhanced Anti‐Inflammatory and Sonodynamic Therapy of Psoriasis2025