Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 11, 2025Advanced Healthcare Materials

Coating Janus Nanoparticles with Immunoregulatory Protein Embedded Membrane for Enhanced Anti‐Inflammatory and Sonodynamic Therapy of Psoriasis

View Full Paper
Ask AI
Bookmark
Share

Authors

CZChunpeng ZhangHCHang ChiXPXinyu Pang

Discussion

Loading...

Member takes

Overview

Cell membrane-coated nanoparticles improve anti-inflammatory effects in psoriasis by targeting t cell activation and reducing inflammatory cytokines.

Key Points

  • The research aims to optimize psoriasis therapy by inhibiting T cell activation and keratinocyte hyperproliferation.
  • Designed cell membrane-coated nanoparticles for targeted delivery.
  • Genetically engineered membrane overexpressing VISTA for T cell inhibition.
  • Co-delivered hydrophilic 5-ALA and hydrophobic tazarotene for enhanced therapy.
  • Evaluated efficacy in a psoriatic mouse model.
  • Significantly reduced lesion severity and epidermal hyperplasia.
  • Suppressed inflammatory cytokine levels in skin lesions.
  • CNPs outperformed non-membrane counterparts in cellular and animal models.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/69252ea8c0ce034ddc356995https://doi.org/10.1002/adhm.202503942
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A programmable nanoplatform for inflammatory-state reprogramming in psoriasis treatment2026
  2. 2A Redox‐Responsive Nanoplatform Modulating the Treg/Th17 Balance Through LAT1‐ and PPARγ‐Related Pathways for Psoriasis Therapy2026
  3. 3Revolutionizing Psoriasis Therapy: Cutting-Edge Nanocarrier Systems, Formulation Strategies, and Future Horizons2026
  4. 4A combination therapy strategy: precision co-targeting of CCR7 and JAK1 with a smart hydrogel for inflammatory skin diseases2026 · 1 citations
  5. 5A Double‐Layer Microneedle Patch Containing Methylprednisolone and Upadacitinib‐Loaded Mesoporous Silica Nanocomposites for Psoriasis Treatment2025