Evaluation of Histological Changes Resulting from the Effect of the Drug Pregnyl on the Histological Structure of The Lungs in the White Mouse Mus Musculus

The present investigation aimed to identify the effect of the drug pregnyl on the histological structure of the lungs in male Swiss mice (Mus musculus). The study included the use of 14 mice divided into two groups, with 14 mice in each group, and the animals of each group were placed in a separate cage. The first group, which is the control group, its animals were treated with distilled water only for 30 days, while the mice of the second group, which is the experimental group, were injected by concentration of 0.2 mg of pregnyl/kg of body weight intraperitoneally, for 30 days too. On the last day, the animals were sacrificed, their lungs were extirpation, and their tissue sections were prepared. The results obtained from the histological study showed that all animals treated with pregnyl exhibited pathological histological changes in the lungs, represented by degeneration and necrosis of the cells lining some bronchi and the separation of some cells from the epithelial layer. It was also noted that there was a gap between the epithelial tissue and the submucosal layer. The results of the study showed the occurrence of edema between the alveoli and alveolar sacs and an increase in the thickness of the wall between the alveoli. On the other hand, congestion and bleeding occurred in the blood vessels, and cellular infiltration was observed between the alveoli and alveolar sacs. It was also noted that there was a break in the wall of the alveoli and alveolar sacs and their accumulation inside the alveolar cavity. It was also noted that there was a collection of inflammatory cells and blood congestion between the alveoli and alveolar sacs. It was also noted that there was a rupture between the alveoli and the occurrence of blood bleeding. The blood vessel was distorted and congested with the appearance of a blood clot inside the blood vessel, in addition to the occurrence of fibrosis and infiltration of inflammatory cells around the vessel. In addition, active transport vesicles inside the vessels appeared, indicating a high activity of the blood vessel lining.