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September 5, 2025International Journal of Applied PharmaceuticsOpen Access

Gc-MS Metabolite Profiling, Total Phenolic, Antioxidant Activity, and in Silico Approach in Chronic Anti-Inflammatory Ethanol Extracts of Polyscias Scutellaria (Burm. F.) Fosberg Leaves

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Authors

ASAlfian SyarifuddinUniversitas Gadjah MadaANArief NurrochmadUniversitas Gadjah MadaNFNanang FakhrudinUniversitas Gadjah Mada

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Implication

Analysis reveals anti-inflammatory potential in polyscias scutellaria extracts, indicating active metabolites may target COX-2 and IL-6 receptors.

Key Points

  • Polyscias scutellaria extracts exhibited significant anti-inflammatory activities, particularly at COX-2 and IL-6 receptors.
  • The total phenolic content was measured at 131.458±8.818 ppm, highlighting the potential antioxidant properties of the extracts.
  • Molecular docking analysis suggested that (S-Z)-Heptadeca-1,9-dien-4,6-diyn-3-ol has a strong binding affinity for anti-inflammatory receptors.
  • Further studies are needed to confirm the biological effects of the identified compounds in clinical settings.

Cite This Study

Syarifuddin et al. (2025) studied this question.

synapsesocial.com/papers/68bb4d2d6d6d5674bcd01648https://doi.org/10.22159/ijap.2025.v17s3.03
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