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September 5, 2025VirusesOpen Access

T-Cell Epitope-Based SARS-CoV-2 DNA Vaccine Encoding an Antigen Fused with Type 1 Herpes Simplex Virus Glycoprotein D (gD)

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Authors

LALuana R. M. M. ApsAVAléxia Adrianne Venceslau-CarvalhoCFCarla Longo de Freitas

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Overview

Prototype DNA vaccine shows improved T-cell responses in mice, indicating potential for broader coronavirus immunity.

Key Points

  • The DNA vaccine led to robust T-cell responses, and mice produced significant interferon-gamma and tumor necrosis factor-alpha.
  • Mice receiving the vaccine showed reduced clinical symptoms and viral burden, demonstrating effective protection against SARS-CoV-2.
  • In silico predictions guided epitope selection targeting HLA class I alleles in the Brazilian population and mouse models.
  • The vaccine's design included fusing T-cell epitopes with glycoprotein D from Herpes Simplex Virus to enhance immunogenicity.

Cite This Study

Aps et al. (2025) studied this question.

synapsesocial.com/papers/68bb4de86d6d5674bcd01975https://doi.org/10.3390/v17091191
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Also Consider

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  5. 5Antigen-Heterologous Vaccination Regimen Triggers Alternate Antibody Targeting in SARS-CoV-2-DNA-Vaccinated Mice2024 · 1 citations