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March 28, 2026Current ProteomicsOpen Access

In silico design and evaluation of a multi-epitope vaccine targeting SARS-CoV-2 structural proteins

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Authors

FAFatemeh Sadat Mirmousavi AmirabadiIslamic Azad University Medical Branch of TehranMDMohadeseh DamirchiIslamic Azad University Medical Branch of TehranMAMelika Saadat AmaniIslamic Azad University, Science and Research Branch

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Overview

Immunoinformatics approach develops a multi-epitope vaccine for SARS-CoV-2, indicating potential for broad immunity.

Key Points

  • The aim is to design a multi-epitope vaccine against SARS-CoV-2 structural proteins using computational techniques.
  • Identified MHC class I, MHC class II, and B-cell epitopes through immunoinformatics.
  • Constructed and evaluated various vaccine candidates through molecular docking and dynamics simulations.
  • Incorporated human β-defensins as adjuvants and optimized constructs for expression in E. coli.
  • Construct 2 showed superior structural stability and interaction with TLR3 and TLR4.
  • Predicted robust activation of B and T lymphocytes and cytokine release.
  • Constructs demonstrated potential for eliciting long-lasting antiviral immunity.

Cite This Study

Amirabadi et al. (2026) studied this question.

synapsesocial.com/papers/69c7725e8bbfbc51511e2db1https://doi.org/10.1016/j.curpro.2026.100088
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