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September 5, 2025Frontiers in Bioscience-LandmarkOpen Access

The Role of Phospholipids in Mitochondrial Dynamics and Associated Diseases

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Authors

SPSolenn PlouzennecJBJuan Manuel Chao de la BarcaACArnaud Chevrollier

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Overview

Review highlights the impact of phospholipid metabolism on mitochondrial dynamics and associated diseases.

Key Points

  • Mitochondrial dynamics significantly depend on phospholipid composition, influencing cellular functions.
  • Originate from intense remodeling processes, cristae and membrane curvature are mainly shaped by phospholipids.
  • Phosphatidylethanolamines and cardiolipins are essential for maintaining mitochondrial integrity and function.
  • Mitochondrial lipids are crucial in pathologies such as cancer and neurodegenerative disorders.

Cite This Study

Plouzennec et al. (2025) studied this question.

synapsesocial.com/papers/68bb4de86d6d5674bcd01b75https://doi.org/10.31083/fbl27634
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Also Consider

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  1. 1The Role of Phospholipid Alterations in Mitochondrial and Brain Dysfunction after Cardiac Arrest2024 · 33 citations
  2. 2Mitochondrial interplay with membrane organelles in health and disease2026 · 1 citations
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  4. 4Perturbations in mitochondrial metabolism associated with defective cardiolipin biosynthesis: An<i>in-organello</i>real-time NMR study2024
  5. 5Mitochondria-Lipid Droplet Communication Remodels Bioenergetic Metabolism in Cardiovascular Diseases.2026