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August 16, 2026Open Access

Beyond Little Handshake: Role of Phospholipids in Health and Disease

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Authors

MOMohammad OwaisCGC. M. Gupta*

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Overview

Narrative review reveals critical roles of phospholipids in cellular signaling and organelle integrity, highlighting their potential as therapeutic targets and disease biomarkers.

Key Points

  • To synthesize current scientific understanding of the multifaceted structural, metabolic, and signaling roles of phospholipids in human health and disease.
  • Narrative review synthesizing literature on phospholipid molecular biology, bio-membrane biogenesis, and organellar compartmentalization.
  • Evaluation of metabolic pathways, secondary signaling networks, and disease models associated with altered phospholipid homeostasis.
  • Phosphatidylethanolamine and cardiolipin maintain mitochondrial cristae structure and drive efficient oxidative phosphorylation.
  • Phosphatidylcholine and phosphoinositides regulate lipoprotein assembly, membrane identity, and the spatial recruitment of signaling enzymes and receptors.
  • Dysregulated phospholipid metabolism and aberrant remodeling are linked to cardiovascular diseases, neurodegeneration, and various forms of cancer.

Cite This Study

Owais et al. (2026) studied this question.

synapsesocial.com/papers/6a817aa1f2fb91fc834ae978https://doi.org/10.5281/zenodo.21948300
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Role of Phospholipids in Mitochondrial Dynamics and Associated Diseases2025
  2. 2Phospholipid metabolism in innate immunity and inflammation: from basic to clinic2025
  3. 3Mammalian Phosphatidylcholine Specific Phospholipase C: Physiological Roles and Disease Implications2026
  4. 4Phosphatidylinositol-Specific Phospholipase C Across Biological Kingdoms: Domain Organization, Functions, and Regulation2025
  5. 5Phosphatidylethanolamine: Structural Component and Beyond2026