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September 5, 2025The Journal of BiochemistryOpen Access

Phosphatidylinositol-Specific Phospholipase C Across Biological Kingdoms: Domain Organization, Functions, and Regulation

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Authors

KKKaori KanemaruYNYoshikazu Nakamura

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Overview

This review highlights the diverse functions of phospholipase C in mammals and plants, suggesting its role in cellular signaling and virulence in bacteria.

Key Points

  • Phosphatidylinositol-specific phospholipase C is vital for regulating cellular processes across different organisms.
  • In mammals, PI-PLCs are involved in key signaling pathways, affecting receptor-mediated cascades.
  • In plants, these enzymes are crucial for growth and responding to stress via inositol phosphate signaling.
  • Bacterial PI-PLCs enhance virulence by targeting host cell membranes, indicating a shared mechanism across kingdoms.

Cite This Study

Kanemaru et al. (2025) studied this question.

synapsesocial.com/papers/68bb3d5b2b87ece8dc95622ahttps://doi.org/10.1093/jb/mvaf051
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Structure, Function, and Control of Phosphoinositide-Specific Phospholipase C2000 · 1,004 citations
  2. 2Mammalian Phosphatidylcholine Specific Phospholipase C: Physiological Roles and Disease Implications2026
  3. 3Emerging Roles of Phospholipase C Beta Isozymes as Potential Biomarkers in Cardiac Disorders2023 · 10 citations
  4. 4Purification of two distinct types of phosphoinositide-specific phospholipase C from rat liver. Enzymological and structural studies1988 · 23 citations
  5. 5BPS2026 – Electrostatic interactions drive membrane association of PLCβ enzymes2026