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This review aims to clarify the physiological roles and disease implications of mammalian phosphatidylcholine-specific phospholipase C (PC-PLC).

July 11, 2026Lipids

Mammalian Phosphatidylcholine Specific Phospholipase C: Physiological Roles and Disease Implications

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This review aims to clarify the physiological roles and disease implications of mammalian phosphatidylcholine-specific phospholipase C (PC-PLC).
Comprehensive integration of current knowledge on PC-PLC across multiple organ systems.
Discussion of PC-PLC functions in hepatic defense, cardiovascular remodeling, and more.
Outline of future research priorities, including structural characterization and lipidomics.
PC-PLC is a central regulator in cell proliferation, immune response, and stress adaptation.
Emerging evidence indicates potential therapeutic strategies targeting PC-PLC in inflammatory and degenerative disorders.
Future work is needed to understand PC-PLC's molecular identity and regulatory mechanisms.

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Review explores the role of phosphatidylcholine-specific phospholipase C in various diseases, indicating therapeutic potential.

Jayaraja et al. (2026) studied this question.

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