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December 20, 2025Cell Communication and SignalingOpen Access

Phospholipase D: emerging therapeutic targets in signaling, metabolism, and immune-oncology

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Authors

LTLin TangYGYunxiao GeYLYuanying Li

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Overview

Review integrates PLD's roles in signaling and metabolism, suggesting targeted therapies for diseases.

Key Points

  • This work aims to explore the diverse roles of phospholipase D isoforms in cellular signaling, metabolism, and immunity to identify therapeutic targets.
  • Review of PLD isoforms' functions in signaling, metabolism, and immune response mechanisms.
  • Analysis of the implications of dysregulated PLD activity in disease contexts such as metabolic syndrome and autoimmune diseases.
  • Discussion on the development of isoform-specific inhibitors for therapeutic applications.
  • Dysregulated PLD activity is linked to metabolic syndrome and autoimmune diseases.
  • PLD coordinates various signaling pathways, including Wnt/β-catenin, PKC, and mTOR, affecting cellular functions.
  • Isoform-specific inhibitors are highlighted as potential therapeutic solutions for advanced understanding of diseases.

Cite This Study

Tang et al. (2025) studied this question.

synapsesocial.com/papers/6a07fa0509b3c82015378ed4https://doi.org/10.1186/s12964-025-02596-z
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Phospholipase D, a Novel Therapeutic Target Contributes to the Pathogenesis of Neurodegenerative and Neuroimmune Diseases2024 · 4 citations
  2. 2Bidirectional regulation of autophagy by PLD: a target for disease treatment2026
  3. 3PLD1 and PLD2 promote an immunosuppressive tumor microenvironment via CCL19-dependent macrophage polarization and PD-L1 induction2026
  4. 4Mammalian Phosphatidylcholine Specific Phospholipase C: Physiological Roles and Disease Implications2026
  5. 5Phospholipid metabolism in innate immunity and inflammation: from basic to clinic2025