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January 10, 2000Physiological Reviews

Structure, Function, and Control of Phosphoinositide-Specific Phospholipase C

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Authors

MRMario J. RebecchiPoliclinico CasilinoSPSrinivas PentyalaStony Brook School

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Overview

Review demonstrates isoform-specific molecular regulation and diverse catalytic mechanisms across species, highlighting coordinated signaling functions in cellular development.

Key Points

  • Summarize recent structural, biochemical, and genetic insights into phosphoinositide-specific phospholipase C (PLC) subtypes beta, gamma, and delta across diverse biological models.
  • Synthesized findings from crystallographic analyses of PLC-delta(1) structural mechanisms and domain organization.
  • Reviewed genetic and cellular signaling studies conducted in model organisms including yeast, slime molds, plants, flies, and mammals.
  • PLC isoforms beta, gamma, and delta act in concert to generate inositol 1,4,5-trisphosphate and diacylglycerol downstream of cell surface receptors.
  • Genetic evidence across model systems reveals distinct, conditional developmental and signaling functions for each subtype rather than generalized calcium-mediated roles.

Cite This Study

Rebecchi et al. (2000) studied this question.

synapsesocial.com/papers/6a6de1bbf44fa9f079dbe23fhttps://doi.org/10.1152/physrev.2000.80.4.1291
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Selectivity in Signal Transduction Determined by γ Subunits of Heterotrimeric G Proteins1993 · 395 citations
  2. 2Proteolytic fragments of phosphoinositide-specific phospholipase C-delta 1. Catalytic and membrane binding properties1993 · 161 citations
  3. 3Role of Phospholipase Cβ3 Phosphorylation in the Desensitization of Cellular Responses to Platelet-activating Factor1997 · 85 citations
  4. 4Drosophila phospholipase C-gamma expressed predominantly in blastoderm cells at cellularization and in endodermal cells during later embryonic stages.1994 · 21 citations