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September 29, 2025SpringerOpen Access

Phospholipid metabolism in innate immunity and inflammation: from basic to clinic

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Authors

JLJuan LiuYCYali ChenLOLuke O'neill

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Overview

This review highlights the impact of phospholipid metabolism on inflammation and innate immunity, suggesting therapeutic targets.

Key Points

  • Phospholipid metabolism influences inflammation and immune responses through lipid signaling.
  • Studies emphasize the potential of phospholipid metabolites as biomarkers and therapeutic targets in diseases.
  • Understanding phospholipid roles in immunity may lead to novel immunotherapy approaches against cancer.
  • Dysregulation of phospholipid metabolism is linked to autoimmune diseases and cardiovascular issues.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68da58d8c1728099cfd1129ahttps://doi.org/10.1007/s44466-025-00001-5
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  4. 4Lipid-Regulated State Transitions in Inflammation, Regeneration, and Chronic Disease2026
  5. 5Phospholipase D: emerging therapeutic targets in signaling, metabolism, and immune-oncology2025