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September 5, 2025Frontiers in ImmunologyOpen Access

Postoperative adhesion formation: the role of peritoneal macrophages and targeting therapy

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Authors

ZLZhongyuan LiuRLRenfeng LiHQHong‐Yan Qin

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Overview

This review analyzes peritoneal macrophages' role in postoperative adhesion, suggesting new prevention and treatment strategies.

Key Points

  • Postoperative adhesion is a common complication from abdominal surgery, often leading to serious issues including bowel obstruction.
  • Peritoneal macrophages play a key role in the complex processes of coagulation and inflammation during adhesion formation.
  • Targeting macrophages in treatment strategies may help prevent postoperative adhesion effectively.
  • Understanding the biological mechanisms behind macrophages in adhesion formation opens new avenues for therapy.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68bb4df56d6d5674bcd02147https://doi.org/10.3389/fimmu.2025.1601642
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cellular and molecular regulation of fibrotic post-operative abdominal adhesions2026
  2. 2Function of Peritoneal Exudate Cells after Abdominal Surgery1993 · 41 citations
  3. 3Targeting HCK in M1 macrophages alleviates postoperative abdominal adhesions by suppressing NF-κB/IL6 axis-driven mesothelial-to-mesenchymal transition2026
  4. 4USP7-mediated stabilization of Snail1 drives macrophage-to-myofibroblast transition and promotes postoperative peritoneal adhesions2026
  5. 5Abstract 1584: Metastasis associated macrophages drive immunosuppression and fibrosis in gastric peritoneal carcinomatosis2026