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September 5, 2025Frontiers in Cellular and Infection MicrobiologyOpen Access

Beyond the stomach: the association between Helicobacter pylori and the spectrum of digestive cancers

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Authors

XHXin HeCZChi ZhuCZChan Zhu

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Overview

Review highlights associations of Helicobacter pylori with various digestive cancers, suggesting complex virulence mechanisms and clinical implications.

Key Points

  • Helicobacter pylori is linked to increased risk of various digestive cancers, with associations varying by cancer type.
  • Epidemiological studies indicate a significantly increased risk of hepatocellular carcinoma (OR 4.75) and biliary tract cancer (OR 4.18).
  • The review synthesizes evidence from numerous studies and examines the multifactorial virulence mechanisms of Helicobacter pylori.
  • Insights gathered herein may facilitate risk stratification for digestive cancers and guide therapeutic innovations against them.

Cite This Study

He et al. (2025) studied this question.

synapsesocial.com/papers/68bb4dfb6d6d5674bcd02389https://doi.org/10.3389/fcimb.2025.1633227
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Also Consider

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  1. 1Immune Evasion of <scp> <i>Helicobacter pylori</i> </scp> and Extra‐Gastric Cancer Risk2026 · 1 citations
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  3. 3Association of Helicobacter pylori with Gallbladder, Pancreatic, and Colorectal Malignancies: A Prospective Observational Study2025
  4. 4Helicobacter Pylori and Gastric Carcinogenesis: Mechanisms, Clinical Implications, and Preventive Strategies2025
  5. 5<i>Helicobacter pylori</i> Pathogenic Factors and Their Interactions With the Gastric Microbiome2025 · 5 citations