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September 5, 2025EJNMMI ResearchOpen Access

Imaging renal mitochondrial dysfunction in chronic kidney disease: a repurposed role for 99mTcTc-MIBI SPECT/CT

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Authors

SPS. ParkCLChae Hong LimSJSo‐Young Jin

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Overview

[99mTc]Tc-MIBI identifies mitochondrial dysfunction in chronic kidney disease, correlating uptake with renal health.

Key Points

  • CKD patients exhibited significantly lower renal [99mTc]Tc-MIBI uptake percentage compared to healthy volunteers.
  • Mean SUV was positively correlated with renal mitochondrial content in CKD patients, indicating potential diagnostic value.
  • AUC for mean SUV as a predictor of CKD was 0.886, showcasing high diagnostic accuracy compared to conventional biomarkers.
  • [99mTc]Tc-MIBI SPECT/CT serves as an effective noninvasive imaging biomarker for assessing renal mitochondrial dysfunction.

Cite This Study

Park et al. (2025) studied this question.

synapsesocial.com/papers/68bb4e016d6d5674bcd026abhttps://doi.org/10.1186/s13550-025-01306-7
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