Supplementary Figure 4 from ERBB2/HER2 Alterations in ctDNA and Metachronous Tissues of Patients with Metastatic Urothelial Cancer

Key Points

Circulating tumor DNA analysis identifies double minutes, indicating genetic alterations in cancer cells.
Whole-genome sequencing highlights the presence of HER2 alterations in ctDNA, suggesting a potential target for therapy.
This investigation provides insights into the genetic landscape of metastatic urothelial cancer via tumor DNA analysis.
The findings may enhance monitoring strategies for patients with metastatic urothelial cancer through ctDNA assessment.

Analysis reveals double minute structures in circulating tumor DNA, suggesting effective monitoring of HER2 alterations.

Supplementary Figure 4. Double minute (DM) inferred from whole-genome sequencing of circulating tumor DNA.

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Vandekerkhove et al. (2025) studied this question.

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