Supplementary Figure 8 from ERBB2/HER2 Alterations in ctDNA and Metachronous Tissues of Patients with Metastatic Urothelial Cancer

Key Points

ERBB2 mutation dynamics were observed in ctDNA and tissues from patients with metastatic urothelial cancer, highlighting its significance.
The study analyzed serial tissue and ctDNA samples to track the evolution of ERBB2 alterations over time in individual patients.
Findings demonstrate the importance of monitoring mutation dynamics in ctDNA as it may reflect tumor behavior and treatment response.
This research suggests that understanding ERBB2 dynamics can help improve therapeutic strategies for metastatic urothelial cancer.

Analysis reveals ERBB2 mutation dynamics in ctDNA and tissues of metastatic urothelial cancer, indicating progression.

Supplementary Figure 8. ERBB2 mutation dynamics across serial tissue and ctDNA samples.

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Vandekerkhove et al. (2025) studied this question.

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