Combination therapy involving mcl-1 and mek inhibitors reduces cell viability in triple-negative breast cancer cells, indicating potential for improved treatment.
Fig. S3 CTB assay showing the effect of combination of drugs on SUM149-R cells. The SUM149-R cells showed a decrease in viability after treatment with the constant doses of AZD5991 (0.5, and 1µM) followed by the different doses of AZD6244.
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Mughees et al. (2025) studied this question.