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September 5, 2025Open Access

Figure S1 from Inhibition of MCL-1 and MEK Overcomes MEK Inhibitor Resistance in Triple-Negative and Inflammatory Breast Cancers

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Inhibition of MCL-1 and MEK shows potential to overcome resistance in specific breast cancer types.
MDR gene expression comparison highlights significant changes between parental and resistant cell lines.
Analysis focuses on triple-negative and inflammatory breast cancers, which show distinct resistance mechanisms.
This research may lead to more effective treatments for aggressive breast cancers that show previous drug resistance.

Comparative analysis reveals MDR gene expression differences in resistant cells with MEK inhibition.

Fig. S1 Comparative analysis of expression of MDR genes in the parental and resistant cells.

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Mughees et al. (2025) studied this question.

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Comparative analysis reveals MDR gene expression differences in resistant cells with MEK inhibition.

Fig. S1 Comparative analysis of expression of MDR genes in the parental and resistant cells.