Supplementary Figure 10 from Anti-HER2, High-DAR Antibody Fragment–Drug Conjugates with a Glucuronide-Based MMAE Linker–Payload Demonstrate Superior Efficacy over IgG-Based ADCs

Ioanna Stamati; Gökhan Yahioglu; Soraya Diez-Posada; Anja Pomowski; Isabel Perez-Castro; A. Keith Stewart; Laura Bouché; Antony Constantinou; Benjamin J. Stenton; Savvas Saouros; Bryan Edwards; Sam Ness; Mahendra P. Deonarain

doi:10.1158/1535-7163.30029717

September 2, 2025Open Access

Supplementary Figure 10 from Anti-HER2, High-DAR Antibody Fragment–Drug Conjugates with a Glucuronide-Based MMAE Linker–Payload Demonstrate Superior Efficacy over IgG-Based ADCs

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Key Points

High-DAR antibody fragments demonstrate superior efficacy compared to traditional IgG-based ADCs, enhancing treatment options.
The relationship between FDC DAR and binding kinetics is illustrated, showing improved dynamics in the new conjugates.
This analysis leverages kinetic data to compare on and off rates, providing insights into therapeutic performance.
Investigations into binding kinetics could lead to further advancements in antibody-drug conjugate designs for HER2-targeted therapies.

Implication

Supplementary figure reveals that high-DAR antibody fragments improve binding kinetics in HER2-targeted therapies, highlighting their potential efficacy.

Abstract

Supplementary Figure showing the relationship between FDC DAR and binding kinetics (on and off rates)

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Cite This Study

Stamati et al. (2025) studied this question.

synapsesocial.com/papers/68bb5f076d6d5674bcd02b29 https://doi.org/10.1158/1535-7163.30029717

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Supplementary Figure 10 from Anti-HER2, High-DAR Antibody Fragment–Drug Conjugates with a Glucuronide-Based MMAE Linker–Payload Demonstrate Superior Efficacy over IgG-Based ADCs

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure 10 from Anti-HER2, High-DAR Antibody Fragment–Drug Conjugates with a Glucuronide-Based MMAE Linker–Payload Demonstrate Superior Efficacy over IgG-Based ADCs

Key Points

Implication

Abstract

Discussion

Cite This Study

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