Supplementary Figure 8 from Anti-HER2, High-DAR Antibody Fragment–Drug Conjugates with a Glucuronide-Based MMAE Linker–Payload Demonstrate Superior Efficacy over IgG-Based ADCs

Ioanna Stamati; Gökhan Yahioglu; Soraya Diez-Posada; Anja Pomowski; Isabel Perez-Castro; A. Keith Stewart; Laura Bouché; Antony Constantinou; Benjamin J. Stenton; Savvas Saouros; Bryan Edwards; Sam Ness; Mahendra P. Deonarain

doi:10.1158/1535-7163.30029696

September 2, 2025Open Access

Supplementary Figure 8 from Anti-HER2, High-DAR Antibody Fragment–Drug Conjugates with a Glucuronide-Based MMAE Linker–Payload Demonstrate Superior Efficacy over IgG-Based ADCs

View Full Paper

Ask AI

Bookmark

Share

Key Points

Lower liver toxicity markers were observed in high-DAR antibody fragment-drug conjugates compared to IgG-based ADCs, indicating improved safety.
Liver toxicity markers AST and ALT were found to be insignificant in the tested formulations, supporting their favorable profile.
Assessment of liver and kidney histology showed negligible tissue damage, suggesting minimal side effects from the antibody fragment-drug conjugates.
The findings may enable the development of safer therapeutic options for targeting HER2 in cancer treatments.

Implication

Observational analysis shows lower liver toxicity markers in antibody fragment-drug conjugates, suggesting better tolerability.

Abstract

Supplementary Figure 8 showing liver toxicity markers (AST and ALT) for TCT(H) scFv, FDC, trastuzumab IgG and ADC and corresponding liver and kidney histology showing insignificant tissue damage

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Stamati et al. (2025) studied this question.

synapsesocial.com/papers/68bb5f076d6d5674bcd02b33 https://doi.org/10.1158/1535-7163.30029696

View Full Paper

Ask AI

Bookmark

Share

Supplementary Figure 8 from Anti-HER2, High-DAR Antibody Fragment–Drug Conjugates with a Glucuronide-Based MMAE Linker–Payload Demonstrate Superior Efficacy over IgG-Based ADCs

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure 8 from Anti-HER2, High-DAR Antibody Fragment–Drug Conjugates with a Glucuronide-Based MMAE Linker–Payload Demonstrate Superior Efficacy over IgG-Based ADCs

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading