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September 5, 2025ACS Synthetic BiologyOpen Access

Complex Kinetic Models Predict β-Carotene Production and Reveal Flux Limitations in Recombinant Saccharomyces cerevisiae Strains

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Authors

BEBenjamín R. ElizondoPSPedro A. Saa

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Overview

Kinetic models predict β-carotene production in recombinant Saccharomyces cerevisiae, highlighting key flux limitations.

Key Points

  • Detailed kinetic models unveiled factors limiting β-carotene production in yeast strains, improving production efficiency.
  • The promiscuous CrtYB enzyme was shown to exert the highest control over β-carotene production across growth rates.
  • Evaluation of kinetic models revealed that upregulation of ERG10 was not an effective intervention for increasing production.
  • This work facilitates in silico metabolic prospection and guides rational design of genetic interventions in Saccharomyces cerevisiae.

Cite This Study

Elizondo et al. (2025) studied this question.

synapsesocial.com/papers/68bb5f076d6d5674bcd02cd4https://doi.org/10.1021/acssynbio.5c00256
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