Clinical comparison of simultaneous integrated and sequential boost IMRT of tumor bed after breast conserving surgery

Background: To explore the clinical effect compare between the simultaneous-integrated boost and sequential-boost intensity modulated radiotherapy in early breast cancer patients after breast conserving surgery. Methodology: According to the different postoperative radiotherapy methods, 66 early breast cancer patients after breast-conserving surgery were divided into two groups, 34 in the simultaneous-integrated boost group and 32 in the sequential-boost intensity group. Adverse reactions, cosmetic effects, local recurrence rate, progression-free survival and overall survival rates were compared. Results: No statistical significance in the incidence of acute skin reaction, advanced skin reaction, myelosuppression, radiation pneumonia and other adverse reactions between two groups were observed. The fine rate of simultaneous-integrated boost group was slightly better than the sequential-boost intensity group. And the follow-up rate of the two groups was 100%. The progression-free survival rate of the simultaneous-integrated boost group and the sequential-boost intensity group were 100% and 96.88%, respectively; The overall survival rates of the two groups were all 100%; One patient in the sequential-boost intensity group had recurrence (3.13%), while none in the simultaneous-integrated boost group. No significant difference in local recurrence rate, progression-free survival and overall survival rates in the two groups were found. Conclusion: Simultaneous-integrated boost ensures breast appearance and survival without added radiotherapy side effects vs sequential-boost intensity.