A prospective randomized study of sequential boost versus simultaneous integrated boost intensity-modulated radiation therapy with concurrent chemotherapy in locally advanced head and neck cancer

Key Points

• The aim is to compare the effectiveness and safety of sequential boost versus simultaneous integrated boost radiation therapy in patients with locally advanced head and neck cancer.
• Conducted a prospective randomized trial
• Included patients with locally advanced head and neck cancer
• Compared two radiation therapy techniques with concurrent chemotherapy
• Evaluated treatment time and incidence of dysphagia
• SIB showed reduced overall treatment time
• Higher grades of dysphagia anticipated with SIB
• Management strategies for dysphagia required in both treatment groups