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September 5, 2025HemaSphereOpen Access

Results in pediatric T‐ALL patients treated in trial AIEOP‐BFM ALL 2009: Prognostic factors in the context of modern risk‐adapted therapy

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Authors

GCGunnar CarioKiel UniversityMVMaria Grazia ValsecchiAzienda Ospedaliera San GerardoVCValentino ConterFondazione Matilde Tettamanti Menotti De Marchi

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Overview

Trial AIEOP‐BFM ALL 2009 evaluates treatment outcomes in pediatric T‐ALL patients, revealing critical prognostic factors.

Key Points

  • Five-year event-free survival (EFS) reached 79.9%, with high-risk patients showing significantly lower success rates.
  • High PCR-based minimal residual disease (MRD) levels were strong prognostic indicators, influencing treatment stratification.
  • Cox regression models identified factors like CNS3 involvement and EOI-MRD as crucial in determining patient outcomes.
  • The study emphasizes the importance of predictive factors for future treatment protocols in pediatric T‐ALL management.

Cite This Study

Cario et al. (2025) studied this question.

synapsesocial.com/papers/68bb5f3e6d6d5674bcd03320https://doi.org/10.1002/hem3.70206
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Late MRD response determines relapse risk overall and in subsets of childhood T-cell ALL: results of the AIEOP-BFM-ALL 2000 study2011 · 442 citations
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  3. 3Incidence and Characteristics of Hypersensitivity Reactions to PEG-asparaginase Observed in 6136 Children With Acute Lymphoblastic Leukemia Enrolled in the AIEOP-BFM ALL 2009 Study Protocol2023 · 20 citations
  4. 4Use of Minimal Residual Disease Assessment to Redefine Induction Failure in Pediatric Acute Lymphoblastic Leukemia2017 · 86 citations
  5. 5Standardization of flow cytometric minimal residual disease evaluation in acute lymphoblastic leukemia: Multicentric assessment is feasible2008 · 157 citations