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September 5, 2025Journal of Medical ToxicologyOpen Access

Comparison of Crotalidae Immune F(ab’)2 (Equine) and Crotalidae Polyvalent Immune Fab (Ovine) at Establishing Control of Initial Envenomation Symptoms in Louisiana Agkistrodon Envenomations

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Authors

TSTaylor SandersCMChristine MurphyGDGreggory R. Davis

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Overview

Retrospective study comparing antivenom types for copperhead and cottonmouth bites, suggesting FabAV may be more effective.

Key Points

  • Control of symptoms was achieved more often with FabAV, as it required fewer additional doses compared to Fab2AV.
  • In the FabAV cohort, 16% needed more vials for control after the first dose, while 56% of the Fab2AV cohort required additional treatment.
  • This study analyzed 100 cases of Agkistrodon envenomations in Louisiana, comparing the effectiveness of two antivenoms.
  • Identifying the best antivenom may lead hospitals in Agkistrodon-endemic regions to stock FabAV preferentially.

Cite This Study

Sanders et al. (2025) studied this question.

synapsesocial.com/papers/68bb5f3e6d6d5674bcd034c9https://doi.org/10.1007/s13181-025-01093-6
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