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September 5, 2025BiomoleculesOpen Access

Impact of D-Amino Acids in Schizophrenia

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Observational analysis reveals reduced d-amino acids in schizophrenia patients, suggesting various receptor roles.

Reduced levels of d-amino acids are associated with schizophrenia-relevant behaviors in preclinical studies.
Clinical studies have shown decreased d-serine, d-aspartate, and d-alanine levels in schizophrenia patients.
Manipulating d-amino acid levels may offer new therapeutic approaches alongside antipsychotics for schizophrenia.
The presence of d-cysteine in the brain and its role in development suggest further avenues for research.

Dursun et al. (2025) studied this question.

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