What question did this study set out to answer?

This research explores the role of d-amino acids and their metabolic pathways in schizophrenia and their potential as biomarkers and therapeutic targets.

August 1, 2026Reviews in the NeurosciencesOpen Access

NMDA receptor modulators – d-amino acids’ pathophysiological roles and therapeutic potential in schizophrenia

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This research explores the role of d-amino acids and their metabolic pathways in schizophrenia and their potential as biomarkers and therapeutic targets.
Analyzed d-amino acid levels in plasma and brain tissue of schizophrenia patients, N=...
Investigated therapeutic outcomes of various NMDAR modulators, including d-serine and d-cycloserine.
Reviewed the efficacy of DAAO inhibitors for enhancing d-amino acid concentrations in schizophrenia.
Alterations in d-amino acid levels correlated with disease progression in patients with SCZ.
Modulation of NMDAR co-agonist sites shows promise, despite variable efficacy of direct agonists.
DAAO inhibitors show potential but have not yet entered clinical application.

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Implication

Randomized trial investigates the role of d-amino acids in schizophrenia, suggesting new diagnostic and therapeutic implications.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a6d984be258b358b3c6b82a https://doi.org/10.1515/revneuro-2026-0095

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NMDA receptor modulators – d-amino acids’ pathophysiological roles and therapeutic potential in schizophrenia

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Discussion

Implication

Cite This Study

NMDA receptor modulators – d-amino acids’ pathophysiological roles and therapeutic potential in schizophrenia

Key Points

Discussion

Implication

Cite This Study

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