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September 5, 2025Journal of Natural Products

Bioactive Cyclodepsipeptides from Cocultured Mangrove-Derived Aspergillus sp. and Penicillium sp.

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Authors

YWYu WangGCGuang-Ping CaoXQXin-Jian Qu

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Overview

Research reports on the antibacterial and cytotoxic effects of cyclodepsipeptides from Aspergillus and Penicillium, suggesting potential as therapeutic agents.

Key Points

  • Compounds 1 and 5 showed weak cytotoxicity against MHCC-97H cells, indicating selective cell impact.
  • Compound 4 demonstrated potent anti-BPH activity with an IC50 of 0.36 μM, highlighting its potential as a therapeutic.
  • The study utilized 1H NMR-guided fractionation, showcasing an innovative method for compound isolation and analysis.
  • These findings suggest further investigation into the bioactive compounds for possible pharmaceutical applications.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68bb5f586d6d5674bcd038c8https://doi.org/10.1021/acs.jnatprod.5c00752
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Two New Pentadepsipeptides from the Mangrove Fungus Aspergillus sp. SCSIO 414432026 · 2 citations
  2. 2New Cyclic Pentapeptides from the Mangrove-Derived Aspergillus fumigatus GXIMD 030992024 · 13 citations
  3. 3New Prenylated Isoindolinone Alkaloids and Polyketides from the Mangrove-Derived Fungus Aspergillus sp. SCSIO 414402026
  4. 4Antimicrobial compounds of an actinomycete derived from mangrove sediments2024
  5. 5Two new polyketide derivatives isolated from the mangrove-derived fungus <i>Aspergillus</i> sp. GXNU 2Y102026