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Research reports on the antibacterial and cytotoxic effects of cyclodepsipeptides from Aspergillus and Penicillium, suggesting potential as therapeutic agents.
Three new arthrichitin derivatives I–K (1–3) and three known congeners (4–6) were isolated from a coculture of mangrove-derived fungi Aspergillus sp. and Penicillium sp. using 1H NMR-guided fractionation. Their structures were determined by comprehensive spectroscopic analysis (1D/2D NMR, HRESIMS, ESI-MS/MS), Marfey's analysis, DP4+ probability, and experimental/computed ECD comparison. All compounds were evaluated for antibacterial effects and cytotoxicity. Notably, compounds 1 and 5 showed weak cytotoxicity against MHCC-97H cells (IC50 = 20.1 ± 0.9 and 25.8 ± 0.4 μM, respectively). Compound 4 exhibited potent anti-BPH activity (IC50 = 0.36 ± 0.02 μM).
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Wang et al. (2025) studied this question.
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