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September 5, 2025International Journal of HematologyOpen Access

Outcomes of patients aged 70 years or younger with aggressive ATL at core hospitals for ATL treatment in Tokyo

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Authors

JMJunya MakiyamaNONobuhiro OhnoKJKoji Jimbo

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Overview

Retrospective study shows overall survival differences in aggressive atl treated with allo-hsct, highlighting the role of core hospitals.

Key Points

  • Patients receiving allogeneic hematopoietic stem cell transplantation had a significantly higher overall survival rate of 45.7%.
  • Outcomes were notably better for those in complete or partial remission before allo-HSCT, achieving 51.4% survival.
  • A significant 64.8% of 71 patients underwent allo-HSCT, indicating its prevalence in treatment for aggressive ATL.
  • The two-year cumulative incidence of relapse was 41.3%, emphasizing ongoing challenges even after treatment success.

Cite This Study

Makiyama et al. (2025) studied this question.

synapsesocial.com/papers/68bb5f586d6d5674bcd0394dhttps://doi.org/10.1007/s12185-025-04057-2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1[Prevention and treatment of post-transplant relapse in adult T-cell leukemia-lymphoma].2025
  2. 2[Treatment of adult T-cell leukemia/lymphoma: past, present, and future].2025
  3. 3Adult T-cell Leukemia/Lymphoma in Japan: Real-World Treatment Patterns, Healthcare Resource Utilization, and Costs2026
  4. 4Allogeneic transplantation for adult T‐cell leukemia/lymphoma in adolescent and young adults and young patients: A nationwide retrospective study by the ATL working group of the Japan society for transplantation and cellular therapy2024 · 6 citations
  5. 5Distribution of adult T‐cell leukaemia/lymphoma subtypes and survival outcomes across geographical regions: An international retrospective cohort study2026 · 1 citations