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September 10, 2025

Prevention and treatment of post-transplant relapse in adult T-cell leukemia-lymphoma.

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Authors

AIAyumu Ito

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Overview

Observational analysis reveals high relapse rates after allo-HCT in adult T-cell leukemia-lymphoma, suggesting the need for improved treatment strategies.

Key Points

  • Approximately 40% of patients with adult T-cell leukemia-lymphoma relapse after allo-HCT, leading to poor outcomes.
  • Recent strategies like salvage therapy and monitoring measurable residual disease aim to improve post-transplant treatment.
  • Alternate donor sources, including cord blood and related donors, are increasingly used for allo-HCT to improve prognosis.
  • Insufficient evidence remains regarding effective prevention and treatment of post-transplant relapse of ATL.

Cite This Study

Ayumu Ito (2025) studied this question.

synapsesocial.com/papers/68c1bb7854b1d3bfb60eddb2https://doi.org/10.11406/rinketsu.66.612
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Outcomes of patients aged 70 years or younger with aggressive ATL at core hospitals for ATL treatment in Tokyo2025
  2. 2[Treatment of adult T-cell leukemia/lymphoma: past, present, and future].2025
  3. 3Allogeneic Bone Marrow Transplantation from Unrelated Human T-Cell Leukemia Virus-I–negative Donors for Adult T-Cell Leukemia/Lymphoma: Retrospective Analysis of Data from the Japan Marrow Donor Program2007 · 59 citations
  4. 4Allogeneic transplantation for adult T‐cell leukemia/lymphoma in adolescent and young adults and young patients: A nationwide retrospective study by the ATL working group of the Japan society for transplantation and cellular therapy2024 · 6 citations
  5. 5Improvements over time in survival after post‐transplant relapse of adult T‐cell leukaemia/lymphoma and trends of salvage therapy in a real‐world experience2026 · 1 citations