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September 10, 2025Cellular and Molecular Gastroenterology and HepatologyOpen Access

A redundant system of thioredoxin and glutathione is essential for pancreatic acinar integrity

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A profound loss of acinar tissue occurs when both glutathione depletion and acute pancreatitis challenge the system.
Depletion of the glutathione pool leads to pancreatic necrosis, highlighting its essential role in acinar integrity.
Txnrd1Δpanc mice display a more severe progression of acute pancreatitis, indicating the importance of antioxidant systems.
Alterations in the antioxidant systems are closely linked to the body's response to acute pancreatitis, suggesting potential therapeutic targets.

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Implication

Experimental model reveals glutathione and thioredoxin systems safeguard pancreatic acinar cells during acute pancreatitis, suggesting their protective overlap.

Cite This Study

Einwächter et al. (2025) studied this question.

synapsesocial.com/papers/68c182399b7b07f3a060e7e4 https://doi.org/10.1016/j.jcmgh.2025.101627

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Implication

Experimental model reveals glutathione and thioredoxin systems safeguard pancreatic acinar cells during acute pancreatitis, suggesting their protective overlap.

A redundant system of thioredoxin and glutathione is essential for pancreatic acinar integrity

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Discussion

Implication

Cite This Study

A redundant system of thioredoxin and glutathione is essential for pancreatic acinar integrity

Key Points

Discussion

Implication

Cite This Study

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