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This is a Literature Review study.

September 10, 2025PharmaceuticalsOpen Access

Modulation of Macrophage Polarization by Traditional Chinese Medicine in HFpEF: A Review of Mechanisms and Therapeutic Potentials

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Review highlights traditional Chinese medicine's impact on macrophage polarization in HFpEF, indicating therapeutic potentials.

Macrophage polarization plays a crucial role in the pathogenesis of HFpEF, influencing inflammatory responses.
Traditional Chinese medicine shows promise in modulating macrophage activity to exert anti-inflammatory and antifibrotic effects.
Literature review sourced from multiple databases included findings from 19 studies on TCM and macrophage polarization.
Highlights of current challenges include limited HFpEF-specific models, calling for better mechanistic validation.

Liu et al. (2025) studied this question.

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