Why the study?
Despite the high prevalence of HFpEF, no evidence-based guidelines for its management have been generated, and further investigations are needed to elucidate the exact mechanisms underlying HFpEF and the immune-pathogenesis of cardiac fibrosis.
Population
Patients with heart failure with preserved ejection fraction (HFpEF)
Design
Review
Authors
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Highlights macrophages as potential therapeutic target in HFpEF; leaves open whether modulating inflammation improves remodeling or outcomes.
This review highlights the potential pro-inflammatory and profibrotic roles of macrophages in the pathogenesis of HFpEF, suggesting a need for further mechanistic and clinical investigations.
Jinlian Shen (2020) studied this question.
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