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This is a Prospective dose-finding study study.

September 10, 2025Perioperative MedicineOpen Access

Effective doses of alfentanil combined with propofol for gastroscopy in patients of different ages under Narcotrend monitoring: a prospective dose-finding study utilizing the up-and-down sequential allocation method

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The study determines the ED50 of alfentanil and propofol for gastroscopy, particularly assessing age differences.
ED50 for youth was found to be 5.39 µg/kg, while for the elderly group, it was slightly higher at 5.69 µg/kg.
The method employed was a prospective dose-finding study utilizing an up-and-down sequential allocation approach for patient dosing.
These findings support individualized sedation strategies in gastroscopy, highlighting the importance of monitoring sedation depth.

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Prospective dose-finding study finds ED50 of alfentanil combined with propofol in youth and elderly under Narcotrend monitoring.

Jiang et al. (2025) studied this question.

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