What question did this study set out to answer?

This trial aimed to evaluate the impact of alfentanil versus sufentanil on reducing postoperative nausea and vomiting (PONV) in moderate-to-high risk patients during gastrointestinal endoscopy.

May 22, 2026Drug Design Development and TherapyOpen Access

Alfentanil May Reduce Early Postoperative Nausea and Vomiting in Moderate-to-High Risk Patients Undergoing Gastrointestinal Endoscopy: A Prospective Double-Blind Randomized Study

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Authors

XGXiaoyu GuSecond Affiliated Hospital of Xi'an Jiaotong University JCJin-Feng CaoXian Yang Central Hospital XZXin-Yang ZhangXian Yang Central Hospital

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Implication

Randomized trial compares alfentanil and sufentanil effects on postoperative nausea in high-risk patients, suggesting alfentanil may improve early recovery quality.

Key Points

This trial aimed to evaluate the impact of alfentanil versus sufentanil on reducing postoperative nausea and vomiting (PONV) in moderate-to-high risk patients during gastrointestinal endoscopy.
Randomized, double-blind trial with 218 patients assigned to receive alfentanil or sufentanil with propofol.
Primary outcome measured was PONV incidence within 24 hours postoperatively.
Additional outcomes included PONV in PACU, hemodynamic profiles, induction and recovery times, and propofol consumption.
The 24-hour PONV incidence was similar between groups (0.95% for alfentanil vs. 3.85% for sufentanil, p=0.21).
During PACU, PONV was significantly lower in the alfentanil group (0.95% vs. 7.69%, p=0.02) and showed lower PONV scores (p=0.02).
Alfentanil resulted in faster induction times (p<0.01) and did not require higher propofol doses compared to sufentanil.

Cite This Study

Gu et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff3ffd674f7c03778d079 https://doi.org/10.2147/dddt.s598415

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Implication

Randomized trial compares alfentanil and sufentanil effects on postoperative nausea in high-risk patients, suggesting alfentanil may improve early recovery quality.

Alfentanil May Reduce Early Postoperative Nausea and Vomiting in Moderate-to-High Risk Patients Undergoing Gastrointestinal Endoscopy: A Prospective Double-Blind Randomized Study

Discussion

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Implication

Key Points

Cite This Study

Alfentanil May Reduce Early Postoperative Nausea and Vomiting in Moderate-to-High Risk Patients Undergoing Gastrointestinal Endoscopy: A Prospective Double-Blind Randomized Study

Discussion

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Implication

Key Points

Cite This Study

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