DMSO (dimethyl sulfoxide) as a two-methyl source: C-H (trideutero)methylation of (iso)quinolines and their N-oxides

Palani Natarajan; Pooja Pooja; Partigya Partigya; Priya Priya; Meena Meena

doi:10.1039/d5ob01252j

January 1, 2025Organic & Biomolecular Chemistry

DMSO (dimethyl sulfoxide) as a two-methyl source: C-H (trideutero)methylation of (iso)quinolines and their N-oxides

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Key Points

The study finds that DMSO is an effective source for trideutero methylation of quinolines and N-oxides.
DMSO has been identified as a versatile methyl source, enhancing (trideutero)methylation efficiency significantly.
The methodology employed in this research primarily utilizes DMSO(-d6) for the methylation process.
These findings highlight DMSO's potential applications in both chemistry and biology, supporting further research in methylation processes.

Implication

Analysis demonstrates DMSO's effectiveness in trideutero methylation of quinolines, implying significant implications in chemistry.

Abstract

(Trideutero)methylation is an important process in both chemistry and biology. In this context, DMSO(-d6) has largely been used as •CH3/•CD3 source. Typically, all known DMSO(-d6)-based (trideutero)methylation procedures: i) employ a...

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Cite This Study

Natarajan et al. (2025) studied this question.

synapsesocial.com/papers/68c182529b7b07f3a060ec2f https://doi.org/10.1039/d5ob01252j

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DMSO (dimethyl sulfoxide) as a two-methyl source: C-H (trideutero)methylation of (iso)quinolines and their N-oxides

Key Points

Implication

Abstract

Discussion

Cite This Study

DMSO (dimethyl sulfoxide) as a two-methyl source: C-H (trideutero)methylation of (iso)quinolines and their N-oxides

Key Points

Implication

Abstract

Discussion

Cite This Study

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