Supplementary Figure S1 from Close Spatial Interactions between Cancer Cells and Cancer-Associated Fibroblasts Suppress Antitumor Immunity

Yuto Naoi; Yumi Inukai; Tomoka Izumikawa; Joji Nagasaki; Takamasa Ishino; Youki Ueda; Yin Min Thu; Miho Fujiwara; Takahiro Baba; Go Makimoto; Ken Suzawa; Kazuhiro Okada; Ken-ichi Yamamoto; Masakiyo Sakaguchi; Shuta Tomida; Yoshinobu Maeda; Shinichi Toyooka; Mizuo Ando; Yosuke Togashi

doi:10.1158/2326-6066.30029326

Key Points

Reduced antitumor immunity was observed when fibroblasts interact closely with cancer cells, and this showcases potential immune suppression.
Coculture models indicated significant differences in IFNɤ production, pointing to the importance of cell interactions in the tumor microenvironment.
This analysis focused on mouse models, assessing how spatial relationships influence immune responses.
Understanding these interactions could lead to new strategies for enhancing cancer treatments and improving immune responses.

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Implication

Observational analysis shows reduced antitumor immunity with cancer-associated fibroblasts, suggesting a complex interaction.

Abstract

Supplementary Figure S1. Characteristic of our used mouse immortalized fibroblasts (FBs) and additional IFNɤ production data between sFB and mFB coculture models

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Naoi et al. (2025) studied this question.

synapsesocial.com/papers/68c182609b7b07f3a060f57b https://doi.org/10.1158/2326-6066.30029326

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Supplementary Figure S1 from Close Spatial Interactions between Cancer Cells and Cancer-Associated Fibroblasts Suppress Antitumor Immunity

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S1 from Close Spatial Interactions between Cancer Cells and Cancer-Associated Fibroblasts Suppress Antitumor Immunity

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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