Supplementary Figure S3 from Close Spatial Interactions between Cancer Cells and Cancer-Associated Fibroblasts Suppress Antitumor Immunity

This is a In Vitro Study study.

Key Points

Findings indicate that cancer cell interactions with fibroblasts suppress antitumor immunity, affecting treatment efficacy.
Crosstalk between TGF-β and periostin was observed in vitro, highlighting the complex tumor microenvironment's role.
Additional in vitro experiments were performed to better understand the mechanisms of cancer cell-fibroblast interactions.
These results suggest that targeting fibroblast signaling pathways may enhance antitumor therapeutic strategies.

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In vitro analysis reveals that crosstalk between TGF-β and periostin may inhibit antitumor immunity.

Supplementary Figure S3. Additional in vitro data on the TGF-β and periostin crosstalk.

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Naoi et al. (2025) studied this question.

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