Supplementary Figure S4 from Close Spatial Interactions between Cancer Cells and Cancer-Associated Fibroblasts Suppress Antitumor Immunity

Key Points

PD-1 blockade improved antitumor immunity in various mouse cancer models, highlighting its therapeutic potential.
In vivo efficacy data supports the effectiveness of PD-1 blockade in boosting immune response against tumors.
Observational analysis of tumor microenvironments revealed significant interactions between cancer cells and fibroblasts.
Enhanced understanding of immune suppression may enable better strategies for cancer therapies targeting fibroblast interactions.

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Analysis shows PD-1 blockade enhances antitumor immunity in cancer models, suggesting a potential therapy improvement.

Supplementary Figure S4. Additional in vivo efficacy of PD-1 blockade

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Naoi et al. (2025) studied this question.

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