Nephroprotective Role of Ichnocarpus frutescens Leaf Extract Against Cisplatin-Induced Renal Injury: Evidence from Rat and HK-2 Cell Models via Nrf2–HO-1–GPX4 Axis Modulation
Experimental analysis shows that ichnocarpus frutescens reduces oxidative stress in renal models, indicating its nephroprotective potential against cisplatin toxicity.
Key Points
ALIF significantly reduced serum creatinine, BUN, uric acid, and electrolyte disturbances in rats, revealing its nephroprotective effect.
Renal protective functions were linked to modulation of the nrf2–ho-1–gpx4 axis, providing a targeted approach to mitigate nephrotoxicity.
The study established that ALIF restored cell viability and reduced oxidative stress in HK-2 cells, emphasizing its cellular protective role.
Histopathological assessments confirmed that ALIF preserved renal architecture, marking its potential as a valuable adjunct in cisplatin chemotherapy.