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An enzymatic assay for rapid and minimally instrumented ganciclovir triphosphate monitoring in infants with congenital cytomegalovirus

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Enzymatic assay detects ganciclovir triphosphate levels in infants with cytomegalovirus, suggesting improved treatment monitoring.

The REACTR assay effectively measures ganciclovir triphosphate levels in infants, improving therapeutic drug monitoring.
Integration of CRISPR-Cas12a technology allows for rapid, reliable detection of drug concentrations in dried blood spots.
Significant differences in ganciclovir triphosphate levels were observed, indicating potential for personalized drug dosing.
This method offers a cost-effective alternative to traditional liquid chromatography mass spectrometry for drug monitoring.

Chernoske et al. (2025) studied this question.

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